![]() 7, 19 – 21 We previously reported that lacrimation might be promoted by an effect of CsA on sensory (afferent) and cholinergic (efferent) nerves, and we hypothesized that its lacrimatory activity may result from an increase of reflex tear flow. 19 – 21 However, little information is available to explain the mechanism underlying this action. ![]() 7 – 9, 17, 18Ī lacrimomimetic effect of CsA eyedrops has also been reported in experimental animal models of dry eye. 1 – 16 These effects are beneficial for the treatment of dry eye in patients with autoimmune diseases such as Sjögren syndrome and in patients with non-Sjögren dry eye and keratoconjunctivitis sicca. 1 – 6 Although the main effect of CsA is immunosuppression, other actions have been reported, such as stimulation of lacrimation and increased conjunctival goblet cell density. A topical preparation of cyclosporine (CsA) has been developed to treat eyes while reducing the side effects associated with systemic administration. ![]()
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